Research on Coumarin Derivatives for Medicinal Purpose. II
نویسندگان
چکیده
منابع مشابه
The Antioxidant Activity of New Coumarin Derivatives
The antioxidant activity of two synthesized coumarins namely, N-(4,7-dioxo-2- phenyl-1,3-oxazepin-3(2H,4H,7H)-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 5 and N-(4-oxo-2-phenylthiazolidin-3-yl)-2-(2-oxo-2H-chromen-4-yloxy)acetamide 6 were studied with the DPPH, hydrogen peroxide and nitric oxide radical methods and compared with the known antioxidant ascorbic acid. Compounds 5 and 6 were synthes...
متن کامل[New coumarin derivatives with expected biological activity].
A number of novel 3-bromo-4-methyl-7-methoxy-8-amino substituted coumarins and 2-substituted 7-bromo-6-methyl-8H-pyrano-benzimidazoles, benzoxazoles and/or benzoxazine-8-ones were synthesized for the purpose of pharmacological evaluation. Some representative compounds showed antitumor activity in vitro on Ehrlich ascites carcinoma in the preliminary testing.
متن کاملAntioxidant Evaluation of Some Coumarin Derivatives
The present study evaluated the antioxidant potential of 28 coumarin derivatives, using three antioxidant assays: DPPH inhibition, total reducing power and NO inhibition. Out of the tested compounds, the most active DPPH free radicals scavengers were the coumarin hydrazide derivatives. These substances were also the only ones among the investigated derivatives that exhibited a moderate reducing...
متن کاملStability of the complexes of some lanthanides with coumarin derivatives. II. Neodymium(III)-acenocoumarol.
A complex of neodymium(III) with 4-hydroxy-3[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one (acenocoumarol) was synthesized by mixing water solutions of neodymium(III) nitrate and the ligand (metal to ligand molar ratio of 1:3). The complex was characterized and identified by elemental analysis, conductivity, IR, 1H NMR and mass spectral data. DTA and TGA were applied to study the composit...
متن کاملIdentification of binding site for coumarin derivatives on human serum albumin
Binding of two CDS viz., 4HC and 7H4MC with HSA was investigated under simulative physiological conditions by spectroscopic methods. Both compounds effectively quenched the intrinsic fluorescence of HSA and the quenching mechanism was observed to be static in both cases. The number of molecules that bind to protein (n) and binding constants (K) as well as thermodynamic parameters viz., ∆H 0 , ∆...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1951
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.71.6_596